+/-Page Size :

Fexofenadine Hydrochloride Suspension
Packing:- Amber Bottle
Indications:- Seasonal Allergic Rhinitis

  • Suspension Presentation
    Each 5 ml Contains:
    Fexofenadine Hydrochloride IP 30 mg



    Fexofenadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Fexofenadine is used to treat the symptoms of seasonal allergies (hay fever) in adults and children. It is also used to treat skin itching and hives caused by a condition called chronic idiopathic urticaria in adults and children.

    Indications

    Seasonal Allergic Rhinitis: Fexofenadine is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. Symptoms treated effectively were sneezing, rhinorrhea, itchy nose, itchy throat and red eyes.
    Chronic Idiopathic Urticaria: Fexofenadine is indicated for treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 years of age and older. It significantly reduces pruritus and the number of wheals.

    Pharmacology

    Pharmacokinetics:
    Absorption: Fexofenadine hydrochloride was rapidly absorbed following oral administration of a single dose of two 60 mg capsules to healthy male volunteers with a mean time to maximum plasma concentration occurring at 2.6 hours post-dose. After administration of a single 60 mg capsule to healthy volunteers, the mean maximum plasma concentration was 131 ng/mL. Following single dose oral administrations of either the 60 and 180 mg tablet to healthy adult male volunteers, mean maximum plasma concentrations were 142 and 494 ng/mL, respectively. The tablet formulations are bioequivalent to the capsule when administered at equal doses. Fexofenadine hydrochloride pharmacokinetics are linear for oral doses up to a total daily dose of 240 mg (120 mg twice daily). The administration of the 60 mg capsule contents mixed with applesauce did not have a significant effect on the pharmacokinetics of fexofenadine in adults. Co-administration of 180 mg fexofenadine hydrochloride tablet with a high fat meal decreased the AUC and Cmax of fexofenadine by 21 and 20% respectively.
    Distribution:Fexofenadine hydrochloride is 60% to 70% bound to plasma proteins, primarily albumin and a1-acid glycoprotein.
    Metabolism: Approximately 5% of the total dose of fexofenadine hydrochloride was eliminated by hepatic metabolism.
    Elimination: The mean elimination half-life of fexofenadine was 14.4 hours following administration of 60 mg twice daily in healthy volunteers. Human mass balance studies documented a recovery of approximately 80% and 11% of the [14C] fexofenadine hydrochloride dose in the feces and urine, respectively. Because the absolute bioavailability of fexofenadine hydrochloride has not been established, it is unknown if the fecal component represents primarily unabsorbed drug or the result of biliary excretion.

    Mode of Action

    Fexofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective peripheral H1-receptor antagonist activity. Both enantiomers of fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects. Fexofenadine hydrochloride inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats. The clinical significance of these findings is unknown. In laboratory animals, no anticholinergic or alpha1-adrenergic blocking effects were observed. Moreover, no sedative or other central nervous system effects were observed. Radiolabeled tissue distribution studies in rats indicated that fexofenadine does not cross the blood-brain barrier.

    Adverse Effects

    The most commonly reported adverse effects are:
    ⇛ Nausea.
    ⇛ Diarrhea
    ⇛ Drowsiness
    ⇛ Headache.

    Driving and Using Machineries

    "This medication is not applicable since they are intended for use in children from 6months to 12 years of age."
    "However, this information is relevant to the active Ingredients, Fexofenadine hydrochloride."
    "Caution when driving or operating machinery."
    "Response to medication may vary from one individual to another, contain side effects like (vertigo, dizzies nervousness, insomnia) that have been reported very rarely with the medicine may affect some patient's ability to drive, operate machinery."

    Conclusion

    From the above discussion, it can be concluded that this Fexofenadine suspension could improve the quality of life with Seasonal Allergic Rhinitis and Chronic Idiopathic Urticaria.

    We are making superior quality of Fexofenadine Suspension that is used for Treatment of seasonal allergic rhinitis and chronic idiopathic urticaria. Our offered suspension is processed using high grade chemical compounds and other required drugs by our experienced quality controllers that ensure its quality, purity and chemical properties. Highly treasured among the clients for its reliability, accurate composition, excellent physical and purity, this suspension is offered to our esteemed clients at the market leading prices.
To The Top