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Diclofenac Sodium & Thiocolchicoside Tablet
Packing:- 10 x 10 (Alu- Alu)
Indications:- Muscle Relaxant, Anti-Inflammatory, Analgesic and Anesthetic

  • Tablet Presentation
    1.Each Film Coated Tablets Contains:
    Diclofenac Sodium IP 50 mg
    Thiocolchicoside IP 8 mg

    2.Each Film Coated Tablets Contains:
    Diclofenac Sodium IP 50 mg
    Thiocolchicoside IP 8 mg

    Diclofenac sodium is a non steroidal anti - inflammatory drug that helps relieve pain, stiffness, and swelling caused by several types of arthritis, including osteoarthritis and rheumatoid arthritis.
    Thiocolchicoside (THC) is used clinically for its muscle relaxant, anti-inflammatory, and analgesic properties, and it has been shown to interact with g-amino butyric acid (GABA) type a receptors (GABAARs) and strychnine sensitive Glycine receptors in the rat central nervous system.

    It acts as a competitive GABAA receptor antagonist and also inhibits glycine receptors with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizureprone individuals.

    Indications

    Thiocolchicoside:
    Thiocolchicoside binds to GABA-A and strychnine sensitive glycine receptors. Thiocolchicoside acting as a GABA-A receptor antagonist, its myorelaxant effects could be exerted at the supra-spinal level, via complex regulatory mechanisms, although a glycinergic mechanism of action cannot be excluded. The characteristics of the interaction of Thiocolchicoside with GABA-A receptors are qualitatively and quantitatively shared by its main circulating metabolite, the glucuronidated Derivative.
    Thiocolchicoside is rapidly absorbed after oral administration, and metabolized into 3 main metabolites. The two main circulating forms were the Thiocolchicoside aglycon and the glucuronidated derivative of Thiocolchicoside, which is active. Thiocolchicoside is well tolerated oral administration for periods of up to 6 months.

    It has a relaxant effect on skeletal muscle. It also has anti-inflammatory, analgesic and anesthetic actions.

    Diclofenac Sodium:
    Diclofenac is in a group of drugs called nonsteroidal anti- inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

    Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis.

    Drug Interactions

    Drugs that can potentially interfere with diclofenac sodium include diuretics, other nonsteroidal anti-inflammatory drugs, and some herbal supplements. These interactions may increase the risk of kidney damage, reduce the activity of diuretics, or make ACE inhibitors less effective, among other things. If diclofenac sodium drug interactions are a concern, your healthcare provider may adjust your dosage or monitor you more closely.

    Adverse Effects

    ⇛Heart Attack
    ⇛High blood pressure
    ⇛Stomach pain
    ⇛Constipation
    ⇛Diarrhea
    ⇛Heart burn
    ⇛Nausea
    ⇛Vomiting
    ⇛Dizziness

    Thiocolchicoside can cause some side effects. If they do occur, the side effects of Thiocolchicoside are most likely to be minor and temporary.
    However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately. It is pertinent to note that side effects of Thiocolchicoside cannot be anticipated.
    If any side effects of Thiocolchicoside develop or change in intensity, the doctor should be informed as soon as possible.

    Contraindications

    Hypersensitivity, pregnant patients, asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
    "The long term continuous use may increase the risk a heart attack or stroke"

    ⇛In patients in whom substances with a similar action (e.g. aspirin, or other NSAIDs), precipitate attacks of asthma, bronchospasm, acute rhinitis or urticaria or patients are hypersensitive to these drugs.
    ⇛ Severe heart failure or severely impaired hepatic or renal organ function and during the last three months of pregnancy.

    Conclusion

    This is a new combination for a muscle relaxant and displays anti - inflammatory and analgesic properties. Thiocolchicoside & Diclofenac Sodium is well absorbed from the gastrointestinal tract. It shows its effect in 1 - 2 hr after oral administration. This combination is used to treat various painful inflammatory conditions. Diclofenac Sodium has an outstanding anti-inflammatory profile mediated primarily through inhibition of cyclooxygenase (COX) activity and suppression of PGE2 synthesis From the above discussion, it can be concluded that this medicine could improve the quality of life of patients with as well as muscle relaxant in addition. Moreover it has a considerable safety profile, with persistent results.
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