+/-Page Size : 
Methylcobalamin,Benfotiamine & etc. Combination Capsule
Packing:- 10 x 10 (Alu- Alu)Indications:- Diabetic Neuropathy, Alcoholic Neuropathy, Drug-induced Neuralgia
-
Capsule Presentation Each Hard Gelatin Capsules Contains:
Mecobalamin JP - 1000 mcg
Alphalipoic Acid USP - 200 mg
Vitamin B6 IP - 3 mg
Folic Acid IP - 1.5 mg
Inositol BP - 100 mg
Benfotiamine BP - 100 mg
Methylcobalamin is an essential nutrient for neurons and Alpha Lipoic Acid is a powerful antioxidant that protects the neurons from oxidative stress.
Indications and Usage
The trio of Methylcobalamin, Pyridoxine and Folic Acid helps in bringing down the plasma level of homocysteine, the major risk factor for Atherosclerosis. Alpha Lipoic Acid prevents plaque formation in the arteries by preventing LDL oxidation. Thus this combination reduces the major risk factors for Atherosclerosis Antioxidant Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. Inositol is a vitamin-like substance. Inositol is used for diabetic nerve pain, panic disorder, high cholesterol, insomnia,cancer, depression, schizophrenia, Alzheimer's disease, attention deficit-hyperactivity disorder (ADHD), autism, promoting hair growth, a skin disorder called psoriasis, and treating side effects of medical treatment with lithium.
Mechanism of Action
It helps to reduce the excess biosynthesis and accumulation of a variety of glucose metabolites, including glyceraldeyde-3-phosphate and dihydroxyacetone phosphate. Increased concentrations of these glucose intermediates serve as a trigger to many of the mechanisms responsible for hyperglycemia-induced cell damage. Benfotiamine increases tissue levels of thiamine diphosphate, in turn increasing transketolase activity and resulting in a significant reduction in glucose metabolites. Inositol is synthesized from glucose-6-phosphate and metabolized to phosphatidylinositol, which makes up a small, but very significant, component of cell membranes. It helps to reduce the excess biosynthesis and accumulation of a variety of glucose metabolites, including glyceraldeyde-3-phosphate and dihydroxyacetone phosphate. Increased concentrations of these glucose intermediates serve as a trigger to many of the mechanisms responsible for hyperglycemia-induced cell damage. Benfotiamine increases tissue levels of thiamine diphosphate, in turn increasing transketolase activity and resulting in a significant reduction in glucose metabolites. Inositol is synthesized from glucose-6-phosphate and metabolized to phosphatidylinositol, which makes up a small, but very significant, component of cell membranes.
Pharmacology
Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamine B1). After absorption, benfotiamine can be dephosphorylated by cells bearing an ecto-alkaline phosphatase to the lipid-soluble S-benzoylthiamine. Benfotiamine should not be confused with allithiamine, a naturally occurring thiamine disulfide derivative with a distinct pharmacological profile.
Pharmacokinetics
Benfotiamine is absorbed much better than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 times higher after benfotiamine, the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates. Due to its excellent pharmacokinetic profile this combination should be preferred in treatment of relevant indications. Alpha-lipoic acid is absorbed from the small intestine and distributed to the liver via the portal circulation and to various tissues in the body via the systemic circulation. Alpha-lipoic acid readily crosses the blood-brain barrier. It is found, after its distribution to the various body tissues, intracellularly, intramitochondrialy and extracellularly. Alpha-lipoic acid is metabolized to its reduced form, dihydrolipoic acid (DHLA), by mitochondrial lipoamide dehydrogenase.
Contraindications
Hypersensitivity to any ingredient of the composition. Anaphylactic reaction and other sensitivity reactions.
Drug Interactions
Benfotiamine has no known negative interactions with any medications.
Methylcobalamin:
Absorption of vitamin B12 from the GI tract may be decreased by aminoglycoside antibiotics, colchicine, extended-release potassium preparations, aminosalicylic acid and its salts, anticonvulsants (e.g., phenytoin, Phenobarbital, primidone), cobalt irradiation of the small bowel, and by excessive alcohol intake lasting longer than 2 weeks. Neomycin-induced malabsorption of vitamin B12 may be increased by concurrent administration of colchicine.
Alphaliopic Acid:
Alpha lipoic acid may improve blood sugar control, so people with diabetes who are taking medication to lower blood sugar, such as metformin, glyburide, should only take alpha lipoic acid under the supervision of a qualified health professional and have their blood sugar levels carefully monitored.
Inositol:
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with Inositol Nicotinate.
Benefits
The primary use of this antioxidant is as an "anti-AGE" supplement.
⇛ Useful in various Neuropathies like Diabetic Neuropathy, Alcoholic Neuropathy, Drug-induced Neuralgia
storage
Store at room temperature, 15-30° C (59-86°F). Keep away from moisture.